Endocrine Abstracts

Drospirenone (DRSP) is a potent antimineralocorticoid with progestative and moderate antiandrogenic properties. We have previously shown that DRSP exerts a potent antiadipogenic activity in murine and human preadipocytes through specific antagonism of the MR. In the present study responses to DRSP were investigated in a model of diet-induced obesity for 12 weeks. Female 10-week-old C57bl6 mice were fed with normal chow or a high fat diet (HF, containing 45% fat by calories). M...